Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.47 |
| ▸ | CA9 | Q16790 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3166123 | 1.00 | MAPT (0.49) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3156530 | 0.97 | MAPT (0.53) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3156889 | 0.90 | CA12 (0.48) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3156571 | 0.89 | CA12 (0.46) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4276044 | 0.88 | CA12 (0.45) | MAPTLMNAHPGDKMT2ACA12 | |
| SCHEMBL3151655 | 0.86 | MAPT (0.51) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3160688 | 0.85 | CA12 (0.53) | MAPTNPC1RAB9AKMT2ACA12 | |
| SCHEMBL4270707 | 0.85 | CA1 (0.46) | CA12CA1CA2CA9PDK2 | |
| SCHEMBL2120359 | 0.84 | CA1 (0.52) | CA12CA1CA2CA9GAA | |
| SCHEMBL3161624 | 0.84 | CA12 (0.49) | CA12CA1CA2CA9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817287-A1 | AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS | Eli Lilly and Company (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057845-A1 | AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |