Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.75 |
| ▸ | CYSLTR1 | Q9Y271 | 14/20 | 0.75 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200652 | 0.86 | GRM2 (0.59) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL3164262 | 0.85 | CYSLTR1 (1.00) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL3171343 | 0.75 | GRM2 (1.00) | GRM2CYSLTR1CYSLTR2 | |
| SCHEMBL481322 | 0.71 | CYSLTR1 (0.79) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL27856742 | 0.69 | CYSLTR1 (0.61) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL5201693 | 0.68 | GRM2 (0.52) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL13452806 | 0.68 | GRM2 (0.71) | GRM2CYSLTR1 | |
| SCHEMBL5200758 | 0.68 | CYSLTR1 (0.44) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL481031 | 0.67 | CYSLTR1 (0.70) | GRM2CYSLTR1MRGPRX4CYSLTR2 | |
| SCHEMBL6246211 | 0.67 | GRM2 (0.54) | GRM2CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |