Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14337990 | 1.00 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5201423 | 1.00 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL20883210 | 1.00 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14454068 | 1.00 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5204663 | 0.92 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5204658 | 0.92 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5237535 | 0.91 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5207420 | 0.89 | MAPK14 (0.52) | MAPK14CYP2C9CYP2C19CCR3DNMT3A | |
| SCHEMBL14185096 | 0.89 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL20883211 | 0.86 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |
| US-7238712-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-07-03 | — | — | US | claimed |