⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904257 | 0.88 | MAPT (0.34) | — | |
| SCHEMBL2904253 | 0.88 | MAPT (0.34) | — | |
| SCHEMBL7754231 | 0.85 | — | — | |
| SCHEMBL5179262 | 0.85 | — | — | |
| SCHEMBL5207264 | 0.79 | — | — | |
| SCHEMBL2641529 | 0.77 | POLB (0.31) | — | |
| SCHEMBL28069468 | 0.72 | — | — | |
| SCHEMBL5187583 | 0.70 | — | — | |
| SCHEMBL5187579 | 0.70 | — | — | |
| SCHEMBL28089359 | 0.70 | TSHR (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278717-B1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL|-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LAB LTD (IN) | 2007-06-06 | — | — | EP | disclosed |
| EP-1278717-A4 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LAB LTD (IN) | 2005-06-08 | — | — | EP | disclosed |
| US-20040267019-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO -2-[2,4-DIBROMO-3-(DIFLUROMETHOXY) BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | TOYAMA CHEMICAL COMPANY, LIMITED (JP) | 2004-12-30 | — | — | US | disclosed |
| US-6835848-B1 | Reacting 2,4-dibromo-3-(difluoromethoxy)benzoic acid with a halogenating agent to get a corresponding acid chloride, then reacting with a 3-(dialkylamino)acrylic acid alkyl ester and then cyclopropylamine | RANBAXY LABORATORIES LIMITED (IN) | 2004-12-28 | — | — | US | disclosed |
| EP-1278717-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2- 2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | Ranbaxy Laboratories Limited (IN) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001066512-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2-[2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LABORATORIES LIMITED (IN) | 2001-09-13 | — | — | WO | disclosed |
| WO-2001066512-A1 | ONE-POT SYNTHESIS OF ALKYL 3-CYCLOPROPYLAMINO-2-[2,4-DIBROMO-3-(DIFLUOROMETHOXY)BENZOYL]-2-PROPENOATE AS A USEFUL INTERMEDIATE FOR ANTIBACTERIAL QUINOLONE MEDICAMENTS | RANBAXY LABORATORIES LIMITED (IN) | 2001-09-13 | — | — | WO | disclosed |