Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505142 | 0.87 | CDK2 (0.49) | CDK2KCNH2CDK1CDK4CCNT1 | |
| Acetic Acid SCHEMBL4253108 | 0.68 | CDK2 (0.57) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL3207123 | 0.68 | CDK2 (0.60) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL3217346 | 0.68 | CDK2 (0.57) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL4253102 | 0.67 | CDK2 (0.53) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL278830 | 0.65 | CDK2 (0.56) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL4508243 | 0.62 | CDK2 (1.00) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL8950388 | 0.62 | PIK3CA (0.41) | MAPK9CSNK1A1GSK3B | |
| SCHEMBL1447341 | 0.61 | CDK2 (0.81) | CDK2KCNH2CDK1CDK4CCNT1 | |
| SCHEMBL22322804 | 0.60 | CYP2D6 (0.40) | GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |