Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.76 |
| ▸ | MAPK3 | P27361 | 9/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.38 |
| ▸ | STK10 | O94804 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.38 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106641 | 1.00 | BRAF (0.76) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5106650 | 1.00 | BRAF (0.76) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5106722 | 0.93 | BRAF (0.63) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5203298 | 0.93 | BRAF (0.63) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5106719 | 0.93 | BRAF (0.63) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5106232 | 0.91 | BRAF (0.61) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5106229 | 0.91 | BRAF (0.61) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5201207 | 0.91 | BRAF (0.61) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5204757 | 0.90 | BRAF (0.60) | BRAFMAPK3MAPK1BMPR1BCIT | |
| SCHEMBL5115999 | 0.90 | BRAF (0.60) | BRAFMAPK3MAPK1BMPR1BCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423384-B1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2007-05-23 | — | — | EP | claimed |