Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322585 | 0.91 | MAPK14 (0.56) | MAPK14PTGER1 | |
| SCHEMBL5321707 | 0.89 | MAPK14 (0.52) | MAPK14PTGER1MAPK11 | |
| SCHEMBL5202236 | 0.87 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL3522697 | 0.83 | MAPK14 (0.70) | MAPK14PTGER1ROCK2MAPK12MAPK11 | |
| SCHEMBL5203927 | 0.83 | MAPK14 (0.49) | MAPK14PTGER1 | |
| SCHEMBL3525953 | 0.81 | MAPK14 (0.71) | MAPK14PTGER1 | |
| SCHEMBL5209757 | 0.81 | MAPK14 (0.44) | MAPK14 | |
| SCHEMBL5320422 | 0.80 | MAPK14 (0.50) | MAPK14PTGER1MAPK11 | |
| SCHEMBL5206806 | 0.80 | MAPK14 (0.44) | MAPK14 | |
| SCHEMBL5321552 | 0.80 | MAPK14 (0.44) | MAPK14PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | claimed |
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |