Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202334 | 0.89 | MAPK14 (0.44) | MAPK14MAPK11MAPKAPK2 | |
| SCHEMBL5206635 | 0.88 | MAPK14 (0.38) | MAPK14 | |
| SCHEMBL5209133 | 0.88 | MAPK14 (0.41) | MAPK14LMNAMAPK11HTR2AHTR2C | |
| SCHEMBL5233006 | 0.83 | MAPK14 (0.39) | MAPK14LMNAMAPK11P2RX3 | |
| SCHEMBL5204954 | 0.77 | MAPK14 (0.44) | MAPK14 | |
| SCHEMBL5237979 | 0.76 | MAPK14 (0.49) | MAPK14MAPK11MAPKAPK2 | |
| SCHEMBL5202726 | 0.76 | MAPK14 (0.45) | MAPK14 | |
| SCHEMBL5267652 | 0.75 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL5241688 | 0.75 | MAPK14 (0.42) | MAPK14MAPK11MAPKAPK2 | |
| SCHEMBL5209385 | 0.74 | MAPK14 (0.44) | MAPK14MAPK11MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802590-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | Pharmacia & Upjohn Company LLC (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040666-A1 | SUBSTITUTED N-ALKYLPYRIMIDINONES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-04-20 | — | — | WO | disclosed |