Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.87 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.76 |
| ▸ | KIT | P10721 | 2/20 | 0.76 |
| ▸ | AXL | P30530 | 2/20 | 0.76 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.76 |
| ▸ | MET | P08581 | 3/20 | 0.62 |
| ▸ | FLT1 | P17948 | 2/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.62 |
| ▸ | FLT4 | P35916 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | BCR | P11274 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207899 | 0.93 | KDR (0.86) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5208170 | 0.92 | KDR (0.84) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5205592 | 0.89 | KDR (0.69) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5204342 | 0.89 | KDR (0.78) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL1876666 | 0.88 | KDR (0.86) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5203802 | 0.88 | KDR (0.83) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5205102 | 0.88 | KDR (0.83) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5207839 | 0.88 | KDR (0.77) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5206153 | 0.88 | KDR (0.77) | KDRPDGFRAKITAXLFGFR2 | |
| SCHEMBL5203739 | 0.88 | KDR (0.88) | KDRPDGFRAKITAXLFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1384712-B1 | Derivatives of N-((quinolinyl)oxy)-phenyl)-urea and N-((quinazolinyl)oxy)-phenyl)-urea with antitumor activity | KIRIN BREWERY (JP) | 2007-03-07 | — | — | EP | disclosed |
| US-20070027318-A1 | Quinoline derivatives and quinazoline derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-02-01 | — | — | US | disclosed |
| US-7169789-B2 | Quinoline derivatives and quinazoline derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-01-30 | — | — | US | disclosed |
| US-20040209905-A1 | Quinoline derivatives and quinazoline derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 2004-10-21 | — | — | US | disclosed |
| EP-1153920-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES | KIRIN BREWERY (JP) | 2003-10-29 | — | — | EP | disclosed |
| EP-1153920-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES | KIRIN BEER KABUSHIKI KAISHA (JP) | 2001-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027318-A1 | Quinoline derivatives and quinazoline derivatives | CYTH3, NQO2, NRAS | KDR 2466/4885PDGFRA 3108/4885KIT 629/4885 |
| US-20040209905-A1 | Quinoline derivatives and quinazoline derivatives | RABL3, NRAS, CYTH3 | KDR 3106/4885PDGFRA 3103/4885KIT 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.