Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.69 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | FRK | P42685 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3887445 | 0.96 | MAPK14 (0.74) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3890074 | 0.86 | MAPK14 (0.74) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3889480 | 0.84 | MAPK14 (0.56) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3887326 | 0.82 | MAPK14 (1.00) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL1518732 | 0.80 | MAPK14 (0.83) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3891052 | 0.80 | MAPK14 (0.65) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3890898 | 0.79 | MAPK14 (0.78) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3888103 | 0.79 | MAPK14 (0.76) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3890850 | 0.79 | MAPK14 (0.80) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3887338 | 0.78 | MAPK14 (0.74) | MAPK14IKBKBMAPK13PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199124-B2 | JNK inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-04-03 | — | — | US | disclosed |
| EP-1402900-A1 | MEDICINAL COMPOSITIONS | Takeda Chemical Industries, Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| EP-1364949-A1 | JNK INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 2003-11-26 | — | — | EP | disclosed |