Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.44 |
| ▸ | GAK | O14976 | 4/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | STK17B | O94768 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7161673 | 0.87 | CHEK1 (0.48) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL5202877 | 0.82 | PDGFRB (0.48) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL5203291 | 0.76 | CHEK1 (0.48) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL6029081 | 0.74 | PDGFRB (0.58) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL12592207 | 0.71 | PDE4A (0.72) | CHEK1CHEK2PDGFRBPDGFRAAAK1 | |
| SCHEMBL11046284 | 0.71 | PDE4A (0.57) | CHEK1CHEK2PDGFRBPDGFRAAAK1 | |
| SCHEMBL3769943 | 0.71 | PDGFRB (0.58) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL11114300 | 0.70 | CHEK1 (0.48) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL5936909 | 0.70 | PDGFRB (0.54) | CHEK1CHEK2PDGFRBPDGFRADYRK1A | |
| SCHEMBL11047919 | 0.70 | MAPK1 (0.59) | CHEK1CHEK2PDGFRBPDGFRADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358181-B1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-09-26 | — | — | EP | disclosed |
| EP-1358181-A1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050064-A1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |