Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5832289 | 0.87 | GRK6 (0.54) | NPC1CHEK1CHEK2ALDH1A1PDGFRB | |
| SCHEMBL6028508 | 0.80 | FFAR1 (0.48) | NPC1CHEK1CHEK2ALDH1A1MEN1 | |
| SCHEMBL6823193 | 0.78 | NPC1 (0.58) | NPC1ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL14409210 | 0.77 | PDGFRB (0.47) | CHEK1CHEK2PDGFRBPDGFRAKDM4E | |
| SCHEMBL8471824 | 0.76 | NPC1 (0.55) | NPC1ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL6652114 | 0.75 | CHEK1 (0.47) | CHEK1CHEK2PDGFRBPDGFRAFYN | |
| SCHEMBL5832416 | 0.74 | PDGFRB (0.55) | CHEK1CHEK2ALDH1A1MEN1KMT2A | |
| SCHEMBL5832414 | 0.73 | PDGFRB (0.54) | CHEK1CHEK2ALDH1A1MEN1KMT2A | |
| SCHEMBL11046284 | 0.71 | PDE4A (0.57) | NPC1CHEK1CHEK2ALDH1A1MEN1 | |
| SCHEMBL27637469 | 0.71 | FFAR1 (0.59) | MEN1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358181-B1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-09-26 | — | — | EP | disclosed |
| EP-1358181-A1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050064-A1 | SUBSTITUTED PYRROLIDINES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |