Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5208603 | 0.92 | HDAC1 (0.39) | PPARGPPARDPPARAHDAC1FFAR1 | |
| SCHEMBL5205929 | 0.90 | PPARG (0.40) | PPARGPPARDPPARAMMP13SCN9A | |
| SCHEMBL5207965 | 0.89 | PPARG (0.40) | PPARGPPARDPPARAMMP13SCN9A | |
| SCHEMBL5208601 | 0.88 | PPARG (0.39) | PPARGPPARDPPARAMMP13SCN9A | |
| SCHEMBL5208594 | 0.86 | PPARG (0.37) | PPARGPPARDPPARAMMP13NAMPT | |
| SCHEMBL5201675 | 0.86 | PPARG (0.40) | PPARGPPARDPPARASCN9AHDAC1 | |
| SCHEMBL5208785 | 0.83 | PPARG (0.41) | PPARGPPARDPPARASCN9AHDAC1 | |
| SCHEMBL5203547 | 0.83 | PPARG (0.36) | PPARGPPARDPPARAMMP13GLS | |
| SCHEMBL5204846 | 0.82 | HDAC1 (0.42) | PPARGPPARDPPARAHDAC1FFAR1 | |
| SCHEMBL5208608 | 0.82 | PPARG (0.38) | PPARGPPARDPPARAMMP13MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160887-B1 | Aromatic amine derivatives, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-1123918-B1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | TAKEDA PHARMACEUTICAL (JP) | 2005-03-09 | — | — | EP | disclosed |
| EP-1123918-A1 | AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |