Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | RET | P07949 | 4/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.63 |
| ▸ | FLT1 | P17948 | 3/20 | 0.63 |
| ▸ | FLT3 | P36888 | 3/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.63 |
| ▸ | CSF1R | P07333 | 2/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | FLT4 | P35916 | 2/20 | 0.63 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | GMNN | O75496 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202995 | 0.89 | KDR (0.66) | KDRRETFGFR1FLT1FLT3 | |
| SCHEMBL2117299 | 0.82 | KDR (0.80) | KDRRETFGFR1FLT1FLT3 | |
| SCHEMBL2117305 | 0.82 | KDR (0.80) | KDRRETFGFR1FLT1FLT3 | |
| Semaxanib SCHEMBL19571 | 0.78 | RET (1.00) | KDRRETFGFR1FLT1FLT3 | |
| Semaxanib SCHEMBL28266617 | 0.78 | RET (1.00) | KDRRETFGFR1FLT1FLT3 | |
| Semaxanib SCHEMBL29351025 | 0.78 | RET (1.00) | KDRRETFGFR1FLT1FLT3 | |
| Semaxanib SCHEMBL19572 | 0.78 | RET (1.00) | KDRRETFGFR1FLT1FLT3 | |
| Semaxanib SCHEMBL29373311 | 0.78 | RET (1.00) | KDRRETFGFR1FLT1FLT3 | |
| SCHEMBL31672504 | 0.78 | KDR (0.73) | KDRRETFGFR1FLT1FLT3 | |
| SCHEMBL2114209 | 0.78 | KDR (0.73) | KDRRETFGFR1FLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259234-B9 | 3-HETEROARYLIDENYL-2-INDOLINONE COMPOUNDS FOR MODULATING PROTEIN KINASE ACTIVITY AND FOR USE IN CANCER CHEMOTHERAPY | SUGEN INC (US) | 2007-02-14 | — | — | EP | claimed |