Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.69 |
| ▸ | CDK4 | P11802 | 6/20 | 0.69 |
| ▸ | PLK1 | P53350 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 6/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200887 | 0.86 | CDK2 (0.69) | CDK2CDK4PLK1CDK1CCNB1 | |
| SCHEMBL5201943 | 0.85 | CDK4 (0.60) | CDK2CDK4PLK1KDRPTK2 | |
| SCHEMBL5203806 | 0.83 | CDK2 (0.65) | CDK2CDK4KDR | |
| SCHEMBL5206934 | 0.81 | CDK2 (1.00) | CDK2CDK4PLK1AURKBCDK1 | |
| SCHEMBL5201023 | 0.80 | EIF2AK2 (0.63) | CDK2CDK4EIF2AK2 | |
| SCHEMBL5201197 | 0.80 | CDK2 (0.60) | CDK2CDK4SYKEIF2AK2SRC | |
| SCHEMBL4737537 | 0.79 | SYK (0.67) | CDK2CDK4PLK1KDRPTK2 | |
| SCHEMBL5200962 | 0.78 | EIF2AK2 (0.61) | CDK2CDK4PLK1KDRPTK2 | |
| SCHEMBL4614605 | 0.78 | CDK2 (0.63) | CDK2CDK4SYKCDK1CCNB1 | |
| SCHEMBL5206202 | 0.78 | CDK2 (0.58) | CDK2CDK4PLK1AURKBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100519553-C | Inhiitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LTD (GB) | 2009-07-29 | — | — | CN | claimed |
| US-7262202-B2 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2007-08-28 | — | — | US | claimed |
| US-20070185134-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2007-08-09 | — | — | US | claimed |
| EP-1373253-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | CYCLACEL LTD (GB) | 2007-06-20 | — | — | EP | claimed |
| US-20040132746-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2004-07-08 | — | — | US | claimed |
| CN-1503794-A | Inhiitors of cyclin dependent kinases as anti-cancer agent | — | 2004-06-09 | — | — | CN | claimed |
| CN-100519553-C | Inhiitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LTD (GB) | 2009-07-29 | — | — | CN | disclosed |
| US-7262202-B2 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2007-08-28 | — | — | US | disclosed |
| US-20070185134-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20040132746-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2004-07-08 | — | — | US | disclosed |
| CN-1503794-A | Inhiitors of cyclin dependent kinases as anti-cancer agent | — | 2004-06-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185134-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CDK2, CCNK, CDK3 | CDK2 1/4885CDK4 5/4885PLK1 54/4885 |
| US-20040132746-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CDK2, CCNK, CDK3 | CDK2 1/4885CDK4 5/4885PLK1 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.