Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1749545 | 1.00 | MAPT (0.59) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1749546 | 1.00 | MAPT (0.59) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21526534 | 0.92 | MAPT (0.55) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21526519 | 0.92 | MAPT (0.55) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL16569971 | 0.92 | MAPT (0.55) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3635114 | 0.92 | MAPT (0.65) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1749577 | 0.89 | MAPT (0.53) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3551387 | 0.88 | MAPT (0.57) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1749644 | 0.88 | MAPT (0.57) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1749646 | 0.88 | MAPT (0.57) | MAPTPOLBCYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |