Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248679 | 0.89 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL5036458 | 0.88 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL5036533 | 0.88 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL5036528 | 0.88 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL5039492 | 0.85 | EDNRA (0.55) | EDNRAEDNRB | |
| Avosentan SCHEMBL2742679 | 0.84 | EDNRA (1.00) | EDNRAEDNRB | |
| Avosentan SCHEMBL29379732 | 0.84 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL5041577 | 0.82 | EDNRA (0.49) | EDNRAEDNRB | |
| SCHEMBL5032727 | 0.82 | EDNRA (0.49) | EDNRAEDNRB | |
| Avosentan SCHEMBL13391134 | 0.81 | EDNRA (0.91) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185525-B1 | 4-HETEROCYCLYLSULFONAMIDYL-6-METHOXY-5-(2-METHOXY-PHENOXY)-2-PYRIDYL-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | claimed |
| US-6521631-B2 | N-(6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4 -yl)) 5-isopropyl-pyridine-2-sulfonamide; treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction. | HOFFMANN-LA ROCHE INC. | 2003-02-18 | — | — | US | disclosed |