Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549222 | 1.00 | EPHX2 (0.50) | EPHX2MAPTALDH1A1ALOX12HTT | |
| SCHEMBL3554528 | 0.86 | MAPT (0.48) | MAPTALDH1A1ALOX12HTTMMP2 | |
| SCHEMBL9660476 | 0.82 | MAPT (0.56) | MAPTALDH1A1TDP1POLBMCHR1 | |
| SCHEMBL3552399 | 0.82 | MAPT (0.56) | MAPTALDH1A1TDP1POLBMCHR1 | |
| SCHEMBL3552397 | 0.82 | MAPT (0.56) | MAPTALDH1A1TDP1POLBMCHR1 | |
| SCHEMBL3557292 | 0.81 | KDM4E (0.44) | ALDH1A1EPHX1KDM4EMAPK1 | |
| SCHEMBL3885054 | 0.81 | MAPT (0.61) | MAPTALDH1A1HTTPOLBMMP2 | |
| SCHEMBL28149835 | 0.79 | MAPT (0.44) | MAPTALDH1A1TDP1POLBMCHR1 | |
| SCHEMBL30480375 | 0.79 | MAPT (0.42) | MAPTALDH1A1MMP2MMP9MCHR1 | |
| SCHEMBL3552676 | 0.78 | MAPT (0.50) | MAPTALDH1A1MCHR1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |