Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 14/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378900 | 1.00 | MAPK8 (0.41) | MAPK8MAPK9SYKTRPV1IRAK1 | |
| SCHEMBL1378906 | 1.00 | MAPK8 (0.41) | MAPK8MAPK9SYKTRPV1IRAK1 | |
| SCHEMBL5205593 | 1.00 | MAPK8 (0.41) | MAPK8MAPK9SYKTRPV1IRAK1 | |
| SCHEMBL1378901 | 1.00 | MAPK8 (0.41) | MAPK8MAPK9SYKTRPV1IRAK1 | |
| SCHEMBL1377685 | 0.94 | MAPK8 (0.37) | MAPK8MAPK9IRAK1KCNH2SCN9A | |
| SCHEMBL1375327 | 0.94 | MAPK8 (0.37) | MAPK8MAPK9IRAK1KCNH2SCN9A | |
| SCHEMBL1375330 | 0.94 | MAPK8 (0.37) | MAPK8MAPK9IRAK1KCNH2SCN9A | |
| SCHEMBL1377682 | 0.94 | MAPK8 (0.37) | MAPK8MAPK9IRAK1KCNH2SCN9A | |
| SCHEMBL1375333 | 0.94 | MAPK8 (0.37) | MAPK8MAPK9IRAK1KCNH2SCN9A | |
| SCHEMBL1376484 | 0.92 | MAPK8 (0.38) | MAPK8MAPK9SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |