Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 15/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 15/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 15/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823414 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL4823421 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL8269856 | 0.91 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL8269869 | 0.90 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL4822625 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL4822623 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL8319942 | 0.88 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4821903 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8313208 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4821899 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |