Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5211288 | 0.93 | FLT1 (0.35) | FLT1KDR | |
| SCHEMBL14564994 | 0.89 | FLT1 (0.33) | FLT1KDR | |
| SCHEMBL5208321 | 0.86 | PDE4D (0.36) | FLT1KDR | |
| SCHEMBL5210120 | 0.86 | CNR1 (0.32) | FLT1KDR | |
| SCHEMBL5207323 | 0.83 | FYN (0.31) | — | |
| SCHEMBL5208158 | 0.83 | FLT1 (0.35) | FLT1KDR | |
| Hydrochloric Acid SCHEMBL5207976 | 0.83 | FLT1 (0.35) | FLT1KDR | |
| SCHEMBL5210534 | 0.81 | GRM5 (0.35) | — | |
| SCHEMBL5244657 | 0.79 | FLT1 (0.37) | FLT1KDR | |
| SCHEMBL5211498 | 0.79 | FLT1 (0.32) | FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401826-B1 | PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | claimed |
| EP-1401826-A1 | PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-31 | — | — | EP | claimed |
| US-6538015-B1 | Process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is | HOFFMANN-LA ROCHE INC. | 2003-03-25 | — | — | US | claimed |
| WO-2002100853-A1 | PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-19 | — | — | WO | claimed |