Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.65 |
| ▸ | PDE4A | P27815 | 8/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.65 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671425 | 0.88 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL3119101 | 0.88 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL8275008 | 0.86 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL4704186 | 0.86 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL2847332 | 0.85 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL2839762 | 0.84 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL13354230 | 0.84 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL2842068 | 0.83 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL13918308 | 0.82 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL8274723 | 0.81 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664024-B1 | SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS | SCHERING CORP (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1664024-B1 | SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS | SCHERING CORP (US) | 2007-07-11 | — | — | EP | disclosed |
| US-7129357-B2 | Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors | SCHERING CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1664024-A1 | SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS | SCHERING CORPORATION (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050124655-A1 | Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors | SCHERING CORPORATION | 2005-06-09 | — | — | US | disclosed |
| WO-2005028471-A1 | SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS | SCHERING CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
| WO-2005028471-A1 | SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS | SCHERING CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124655-A1 | Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors | PDE3B, PDE4A, PDE5A | PDE4B 6/4885PDE4A 2/4885PDE4C 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.