Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 1.00 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206619 | 0.90 | HRH3 (1.00) | HRH3GPR119SIGMAR1MAOAMAOB | |
| SCHEMBL4237104 | 0.87 | HRH3 (0.85) | HRH3SIGMAR1MAOAMAOBHRH2 | |
| SCHEMBL5210038 | 0.85 | HRH3 (1.00) | HRH3GPR119SIGMAR1MAOAMAOB | |
| SCHEMBL5207819 | 0.85 | HRH3 (0.74) | HRH3SIGMAR1HRH1 | |
| SCHEMBL229024 | 0.84 | HRH3 (1.00) | HRH3GPR119MAOAMAOBFPR2 | |
| SCHEMBL20158437 | 0.84 | HRH3 (0.72) | HRH3GPR119SIGMAR1MLNR | |
| SCHEMBL4237843 | 0.82 | HRH3 (0.72) | HRH3SIGMAR1HRH2HRH1 | |
| SCHEMBL12803875 | 0.82 | HRH3 (0.69) | HRH3 | |
| SCHEMBL14924453 | 0.82 | HRH3 (0.69) | HRH3FPR2PROKR1 | |
| SCHEMBL4227981 | 0.81 | HRH3 (1.00) | HRH3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |
| US-7241778-B2 | Non-imidazole aryloxypiperidines | ORTHO MCNEIL PHARMACEUTICAL, INC (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241778-B2 | Non-imidazole aryloxypiperidines | ORTHO MCNEIL PHARMACEUTICAL, INC (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241778-B2 | Non-imidazole aryloxypiperidines | ORTHO MCNEIL PHARMACEUTICAL, INC (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1311482-B1 | NON-IMIDAZOLE ARYLOXYPIPERIDINES AS H3 RECEPTOR LIGANDS | ORTHO MCNEIL PHARM INC (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1311482-B1 | NON-IMIDAZOLE ARYLOXYPIPERIDINES AS H3 RECEPTOR LIGANDS | ORTHO MCNEIL PHARM INC (US) | 2007-02-21 | — | — | EP | disclosed |
| US-7071191-B2 | Non-imidazole aryloxypiperidines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-20050227979-A1 | Non-imidazole aryloxypiperidines | APODACA RICHARD | 2005-10-13 | — | — | US | disclosed |
| EP-1311482-A2 | NON-IMIDAZOLE ARYLOXYPIPERIDINES AS H3 RECEPTOR LIGANDS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-05-21 | — | — | EP | disclosed |
| US-20020040024-A1 | Non-imidazole aryloxypiperidines | NORTEL NETWORKS LIMITED (CA) | 2002-04-04 | — | — | US | disclosed |
| WO-2002012190-A2 | NON-IMIDAZOLE ARYLOXYPIPERIDINES AS H3 RECEPTOR LIGANDS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | HRH3 1000/4885GPR119 1905/4885SIGMAR1 3807/4885 |
| US-20020040024-A1 | Non-imidazole aryloxypiperidines | HRH2, HRH4, HRH3 | HRH3 3/4885GPR119 153/4885SIGMAR1 56/4885 |
| US-20050227979-A1 | Non-imidazole aryloxypiperidines | HRH2, HRH4, HRH3 | HRH3 3/4885GPR119 153/4885SIGMAR1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.