Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.77 |
| ▸ | PHGDH | O43175 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.63 |
| ▸ | MLYCD | O95822 | 1/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172365 | 0.95 | EPHX2 (0.71) | EPHX2PHGDHKDM4EHPGDHSD11B1 | |
| SCHEMBL3644132 | 0.91 | EPHX2 (0.66) | EPHX2PHGDHKDM4EHPGDHSD11B1 | |
| SCHEMBL10720943 | 0.90 | PHGDH (0.81) | EPHX2PHGDHKDM4EHPGDMLYCD | |
| SCHEMBL3946296 | 0.88 | EPHX2 (1.00) | EPHX2KDM4EHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL22305103 | 0.86 | CA12 (0.71) | EPHX2KDM4EHPGDHSD11B1L3MBTL1 | |
| SCHEMBL6985975 | 0.86 | CA12 (0.71) | EPHX2KDM4EHPGDHSD11B1L3MBTL1 | |
| SCHEMBL28296651 | 0.85 | HPGD (0.86) | EPHX2PHGDHKDM4EHPGDMLYCD | |
| SCHEMBL2199279 | 0.83 | PHGDH (0.71) | EPHX2PHGDHKDM4EHPGDMLYCD | |
| SCHEMBL4696938 | 0.83 | HPGD (0.72) | EPHX2PHGDHKDM4EHPGDMLYCD | |
| SCHEMBL31334408 | 0.82 | HPGD (0.76) | KDM4EHPGDHSD11B1MLYCDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | disclosed |
| US-20060247227-A1 | Substituted piperidines as histamine h3 receptor ligands | BAILEY JAMES M | 2006-11-02 | — | — | US | disclosed |
| EP-1646620-A1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005014571-A1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247227-A1 | Substituted piperidines as histamine h3 receptor ligands | HRH3, HRH4, HRH1 | EPHX2 753/4885PHGDH 1483/4885KDM4E 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.