Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 8/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.63 |
| ▸ | CYP2E1 | P05181 | 4/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.63 |
| ▸ | CYP2B6 | P20813 | 4/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201713 | 0.96 | CYP2A6 (0.62) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL5209764 | 0.92 | CYP2A6 (0.67) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL27585593 | 0.88 | CYP2A6 (0.66) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL12478490 | 0.86 | CYP2A6 (0.76) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL5014459 | 0.85 | CYP2A6 (0.68) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL7588204 | 0.83 | CYP2A6 (0.67) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL1987084 | 0.83 | CYP2A6 (0.67) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL5717914 | 0.82 | CYP2A6 (0.65) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL13750026 | 0.82 | CYP2C9 (0.74) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 | |
| SCHEMBL708867 | 0.82 | CYP2A6 (0.65) | CYP2A6CYP3A4CYP2C19CYP2E1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B8 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2007-04-25 | — | — | EP | disclosed |
| EP-1363925-B1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| US-20060211636-A1 | Macrolide Antibiotics | ALIHODZIC SULEJMAN | 2006-09-21 | — | — | US | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| CN-1492874-A | Macrolide antibiotics | — | 2004-04-28 | — | — | CN | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
| EP-1363925-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002050091-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | CYP2A6 522/4885CYP3A4 341/4885CYP2C19 209/4885 |
| US-20060211636-A1 | Macrolide Antibiotics | IL1R1, MRPL12, RPS21 | CYP2A6 522/4885CYP3A4 341/4885CYP2C19 209/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | CYP2A6 562/4885CYP3A4 500/4885CYP2C19 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.