SCHEMBL5208577

SCHEMBL5208577

O=C1NC(=O)c2cc(S(=O)(=O)O)c3c4cccc5cccc(c6ccc1c2c63)c54

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.44
KMT2A Q03164 6/20 0.40
MEN1 O00255 5/20 0.40
NPSR1 Q6W5P4 2/20 0.40
PKM P14618 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
POLB P06746 5/20 0.38
MAPT P10636 3/20 0.38
RGS12 O14924 1/20 0.38
USP2 O75604 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
THRB P10828 1/20 0.38
CYP2C9 P11712 1/20 0.38
APEX1 P27695 1/20 0.38
CASP1 P29466 1/20 0.38
BRCA1 P38398 1/20 0.38
MTOR P42345 1/20 0.38
RECQL P46063 1/20 0.38
BLM P54132 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30369000 0.79 PARP1 (0.64) PARP1KMT2AMEN1NPSR1PKM
SCHEMBL170580 0.79 PARP1 (0.64) PARP1KMT2AMEN1NPSR1PKM
SCHEMBL5364036 0.78 CDK5 (0.45) PARP1KMT2AMEN1NPSR1POLB
SCHEMBL28394518 0.78 PARP1 (0.55) PARP1KMT2AMEN1NPSR1PKM
SCHEMBL31456289 0.76 PARP1 (0.46) PARP1KMT2AMEN1NPSR1PKM
SCHEMBL27978254 0.76 PARP1 (0.46) PARP1KMT2AMEN1NPSR1PKM
SCHEMBL28394504 0.75 PARP1 (0.55) PARP1KMT2AMEN1NPSR1PKM
Formic Acid SCHEMBL28389359 0.75 PARP1 (0.55) PARP1KMT2AMEN1NPSR1PKM
SCHEMBL8291788 0.73 POLB (0.56) PARP1KMT2AMEN1NPSR1POLB
SCHEMBL17119897 0.72 TYMS (0.36) USP2CYP1A2TDP1ALPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019388-B1 PREPARATION OF PERYLENE-3,4-DICARBOXYLIC ANHYDRIDES CIBA SC HOLDING AG (CH) 2007-03-14 EP disclosed
EP-1019388-A1 PREPARATION OF PERYLENE-3,4-DICARBOXYLIC ANHYDRIDES Ciba SC Holding AG (CH) 2000-07-19 EP disclosed
US-5981773-A REACTING A CORRESPONDING PERYLENE-3,4:9,10-TETRACARBOXYLIC DIANHYDRIDE WITH A STERICALLY HINDERED AMINE, AS A BASE, AT AN ELEVATED TEMPERATURE CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-11-09 US disclosed
WO-1998031678-A1 PREPARATION OF PERYLENE-3,4-DICARBOXYLIC ANHYDRIDES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1998-07-23 WO disclosed