SCHEMBL5209149

SCHEMBL5209149

CCCc1cc(Oc2ccccc2)ccc1OCCCOc1cccc(C2NC(=O)SC2=O)c1

nearest known ligand 0.70

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.70
PPARD Q03181 4/20 0.63
PPARA Q07869 3/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5204909 0.98 PPARG (0.70) PPARGPPARDPPARA
SCHEMBL5759203 0.95 PPARG (0.71) PPARGPPARDPPARA
SCHEMBL5204103 0.94 PPARG (0.65) PPARGPPARDPPARA
SCHEMBL5208705 0.93 PPARG (0.69) PPARGPPARDPPARA
SCHEMBL5205079 0.92 PPARG (0.62) PPARGPPARDPPARA
SCHEMBL5208262 0.91 PPARG (0.67) PPARGPPARDPPARA
SCHEMBL5205755 0.90 PPARG (0.57) PPARGPPARDPPARA
SCHEMBL5208868 0.90 PPARG (0.59) PPARGPPARDPPARA
SCHEMBL5204189 0.89 PPARG (0.60) PPARGPPARDPPARA
SCHEMBL5211160 0.89 PPARG (0.60) PPARGPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007127791-A2 NEW PHARMACOLOGICAL METHOD FOR TREATMENT OF NEUROPATHIC PAIN THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2007-11-08 WO claimed
US-20070249561-A1 Pharmacological method for treatment of neuropathic pain THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND 2007-10-25 US claimed
WO-2000078314-A1 PROCESS FOR MAKING ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO., INC. (US) 2000-12-28 WO claimed
WO-2007127791-A2 NEW PHARMACOLOGICAL METHOD FOR TREATMENT OF NEUROPATHIC PAIN THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2007-11-08 WO disclosed
US-20070249561-A1 Pharmacological method for treatment of neuropathic pain THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND 2007-10-25 US disclosed
EP-1040102-B1 ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO INC (US) 2007-01-24 EP disclosed
EP-1194146-B1 ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES MERCK & CO INC (US) 2006-07-19 EP disclosed
EP-1040102-A4 ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO INC (US) 2002-11-27 EP disclosed
EP-1194146-A4 ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES MERCK & CO INC (US) 2002-07-31 EP disclosed
US-6399640-B1 ANTIDIABETIC AGENTS; ANTICHOLESTEROL AGENTS MERCK & CO., INC. 2002-06-04 US disclosed
EP-1194146-A1 ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES Merck & Co., Inc. (US) 2002-04-10 EP disclosed
WO-2000078314-A8 PROCESS FOR MAKING ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO INC (US) 2001-12-06 WO disclosed
US-6200998-B1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONISTS; ANTICHOLESTEROL, ANTIDIABETIC AND ANTIOBESITY AGENTS MERCK & CO., INC. 2001-03-13 US disclosed
WO-2000078314-A1 PROCESS FOR MAKING ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO., INC. (US) 2000-12-28 WO disclosed
WO-2000078312-A1 ARYLTHIAZOLIDINEDIONE AND ARYLOXAZOLIDINEDIONE DERIVATIVES MERCK & CO., INC. (US) 2000-12-28 WO disclosed
WO-2000078314-A1 PROCESS FOR MAKING ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO., INC. (US) 2000-12-28 WO disclosed
EP-1040102-A1 ARYLTHIAZOLIDINEDIONE DERIVATIVES Merck & Co., Inc. (US) 2000-10-04 EP disclosed
US-6008237-A POTENT AGONISTS OF PEROXIDSOME PROLIFERATOR ACTIVATED RECEPTOR; FOR CONTROLLING OR PREVENTING OF DIABETES, HYPERGLYCEMIA, HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, OBESITY, VASCULAR RESTENOSIS MERCK & CO., INC. (US) 1999-12-28 US disclosed
WO-1999032465-A1 ARYLTHIAZOLIDINEDIONE DERIVATIVES MERCK & CO., INC. (US) 1999-07-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249561-A1 Pharmacological method for treatment of neuropathic pain PPARG, PPARA, CNR2 PPARG 1/4885PPARD 8/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.