Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.71 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.71 |
| ▸ | LYN | P07948 | 1/20 | 0.71 |
| ▸ | RET | P07949 | 1/20 | 0.71 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.71 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.71 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.71 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.71 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.71 |
| ▸ | ADK | P55263 | 1/20 | 0.71 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.71 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210636 | 0.95 | EGFR (0.77) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5210490 | 0.94 | EGFR (0.76) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5210412 | 0.93 | EGFR (0.74) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5210641 | 0.90 | EGFR (0.79) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL13052266 | 0.90 | EGFR (0.82) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5241337 | 0.89 | EGFR (0.77) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5210047 | 0.89 | EGFR (0.85) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL3126385 | 0.87 | EGFR (1.00) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5209599 | 0.87 | EGFR (0.74) | EGFRERBB2GAKRIPK2LYN | |
| SCHEMBL5422908 | 0.86 | EGFR (0.85) | EGFRERBB2GAKRIPK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505878-A | — | — | 2007-03-15 | — | — | JP | claimed |
| US-20070037837-A1 | Antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases;1-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)-L-prolinamide | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | US | claimed |
| EP-1670782-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-02-14 | — | — | EP | claimed |
| EP-1670782-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-06-21 | — | — | EP | claimed |
| WO-2005028470-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | claimed |
| US-20070037837-A1 | Antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases;1-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)-L-prolinamide | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | US | disclosed |
| EP-1670782-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-02-14 | — | — | EP | disclosed |
| EP-1670782-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028470-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037837-A1 | Antiproliferative agent in the prevention or treatment of tumors which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases;1-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}methyl)-L-prolinamide | EGFR, ERBB2, ERBB3 | EGFR 1/4885ERBB2 2/4885GAK 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.