Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484993 | 0.83 | CXCR2 (0.49) | CXCR2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL485642 | 0.83 | CXCR2 (0.55) | CXCR2KDM4EERAP1MEN1KMT2A | |
| SCHEMBL485210 | 0.82 | CXCR2 (0.54) | CXCR2KDM4EERAP1MEN1KMT2A | |
| SCHEMBL485319 | 0.79 | CXCR2 (0.48) | CXCR2KDM4EERAP1LMNAHTT | |
| SCHEMBL3936523 | 0.79 | CXCR2 (0.72) | CXCR2KDM4EERAP1MEN1KMT2A | |
| SCHEMBL485948 | 0.78 | CXCR2 (0.48) | CXCR2KDM4EERAP1LMNA | |
| SCHEMBL3934004 | 0.78 | CXCR2 (0.67) | CXCR2KDM4EDRD2DRD4DRD3 | |
| SCHEMBL485525 | 0.77 | CXCR2 (0.52) | CXCR2KDM4ELMNAHTT | |
| SCHEMBL485465 | 0.77 | CXCR2 (0.52) | CXCR2KDM4ELMNAHTT | |
| SCHEMBL485188 | 0.77 | CXCR2 (0.52) | CXCR2KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | Sanofi-Aventis Deutschland GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069656-A1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-06 | — | — | WO | disclosed |