Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 3/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.45 |
| ▸ | CDK4 | P11802 | 5/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210007 | 0.99 | CDK4 (0.46) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL5209101 | 0.91 | CDK4 (0.49) | CDK4KDRMAPK10GSK3BCDK2 | |
| SCHEMBL5215553 | 0.90 | CDK4 (0.43) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL5208591 | 0.87 | CDK4 (0.54) | CDK4KDRMAPK10GSK3BCDK2 | |
| SCHEMBL5212757 | 0.86 | GAA (0.44) | CDK4KDRMAPK10GSK3BCDK2 | |
| SCHEMBL6105435 | 0.85 | MAPK10 (0.52) | CDK4ADORA1KDRMAPK10GSK3B | |
| SCHEMBL5211093 | 0.84 | CDK4 (0.46) | CDK4KDRMAPK10GSK3BCDK2 | |
| SCHEMBL5210327 | 0.84 | CDK4 (0.46) | CDK4KDRMAPK10GSK3BCDK2 | |
| SCHEMBL6105760 | 0.83 | MAPK10 (0.49) | CDK4ADORA1KDRMAPK10GSK3B | |
| SCHEMBL5211736 | 0.83 | CDK4 (0.48) | CDK4KDRMAPK10GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453830-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-12 | — | — | EP | claimed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | claimed |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION | 2004-12-09 | — | — | US | claimed |
| EP-1453830-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1453830-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | GUDMUNDSSON KRISTJAN | 2007-07-12 | — | — | US | disclosed |
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | GUDMUNDSSON KRISTJAN | 2007-07-12 | — | — | US | disclosed |
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | GUDMUNDSSON KRISTJAN | 2007-07-12 | — | — | US | disclosed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | HRH4, HRH2, HRH1 | PRKAB2 2637/4885PRKAG1 2687/4885PRKAA2 3525/4885 |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | HRH4, HRH1, HRH2 | PRKAB2 2871/4885PRKAG1 2819/4885PRKAA2 3778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.