Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209192 | 0.96 | CDK4 (0.46) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL5208393 | 0.90 | CDK4 (0.50) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL5211736 | 0.87 | CDK4 (0.48) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL5210327 | 0.86 | CDK4 (0.46) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL5208902 | 0.84 | CDK4 (0.48) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL5215553 | 0.80 | CDK4 (0.43) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL5459543 | 0.80 | MAPK14 (0.54) | CDK4KDRGSK3BMAPK8MAPK14 | |
| SCHEMBL6105383 | 0.80 | GSK3B (0.50) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL6106143 | 0.79 | CDK4 (0.48) | CDK4KDRGSK3BCDK2MAPK8 | |
| SCHEMBL6105790 | 0.79 | CDK4 (0.46) | CDK4KDRGSK3BCDK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453830-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | GUDMUNDSSON KRISTJAN | 2007-07-12 | — | — | US | disclosed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | HRH4, HRH2, HRH1 | CDK4 252/4885KDR 2463/4885GSK3B 3007/4885 |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | HRH4, HRH1, HRH2 | CDK4 259/4885KDR 2386/4885GSK3B 2956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.