Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657623 | 0.76 | SMN1; SMN2 (0.41) | TSHRTDP1SMN1; SMN2CYP1A2GLA | |
| SCHEMBL27682692 | 0.76 | TDP1 (0.47) | TSHRTDP1SMN1; SMN2CYP1A2GLA | |
| SCHEMBL10505139 | 0.76 | CYP1A2 (0.57) | TSHRSMN1; SMN2CYP1A2ALDH1A1KMT2A | |
| SCHEMBL11110820 | 0.75 | CYP1A2 (0.54) | TSHRTDP1SMN1; SMN2CYP1A2GLA | |
| Hydrochloric Acid SCHEMBL10504826 | 0.74 | CYP1A2 (0.56) | TSHRSMN1; SMN2CYP1A2ALDH1A1KMT2A | |
| SCHEMBL4726276 | 0.74 | CYP1A2 (0.68) | TSHRCYP1A2ALDH1A1POLBCYP2C19 | |
| SCHEMBL4726270 | 0.74 | CYP1A2 (0.68) | TSHRCYP1A2ALDH1A1POLBCYP2C19 | |
| SCHEMBL7145479 | 0.74 | TDP1 (0.56) | TSHRTDP1SMN1; SMN2CYP1A2GLA | |
| SCHEMBL7723386 | 0.73 | CYP1A2 (0.58) | TSHRCYP1A2ALDH1A1POLBCYP2C19 | |
| SCHEMBL7731632 | 0.73 | CYP1A2 (0.55) | TSHRCYP1A2ALDH1A1POLBCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753763-A2 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Pfizer Limited (GB) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005116027-A2 | INDAZOLE AND INDOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | PFIZER LIMTED (GB) | 2005-12-08 | — | — | WO | disclosed |