Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 9/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520970 | 0.82 | FYN (0.40) | FYNPDE4DDYRK1ADYRK2DYRK1B | |
| SCHEMBL520639 | 0.79 | KDM4E (0.46) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL521425 | 0.77 | FYN (0.50) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL520795 | 0.77 | JAK2 (0.58) | JAK2PTK2 | |
| SCHEMBL522199 | 0.76 | DYRK3 (0.44) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL520494 | 0.75 | DYRK3 (0.45) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL16530364 | 0.74 | JAK2 (0.37) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL521476 | 0.74 | FYN (0.48) | FYNJAK2PTK2 | |
| SCHEMBL519714 | 0.74 | KDM4E (0.52) | FYNDYRK1ADYRK1BJAK2PTK2 | |
| SCHEMBL521447 | 0.73 | JAK2 (0.41) | DYRK1ADYRK2DYRK1BDYRK3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | FYN 195/4885PDE4D 3374/4885DYRK1A 1395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.