Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | TEK | Q02763 | 4/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212728 | 0.88 | MAPK14 (0.50) | MAPK14TEKSLC2A1 | |
| SCHEMBL4882167 | 0.83 | BRAF (0.55) | MAPK14 | |
| SCHEMBL5211714 | 0.83 | MAPK14 (0.55) | MAPK14 | |
| SCHEMBL5219276 | 0.82 | MAPK14 (0.48) | MAPK14TEK | |
| SCHEMBL5212033 | 0.81 | MAPK14 (0.48) | MAPK14TEK | |
| SCHEMBL5219223 | 0.81 | MAPK14 (0.47) | MAPK14TEK | |
| SCHEMBL5212161 | 0.80 | MAPK14 (0.47) | MAPK14TEK | |
| SCHEMBL4885445 | 0.77 | BRAF (0.57) | MAPK14TEKABL1 | |
| SCHEMBL5212408 | 0.76 | MAPK14 (0.45) | MAPK14TEK | |
| SCHEMBL5215642 | 0.73 | MAPK14 (0.47) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761506-A1 | SUBSTITUTED QUINAZOLONES AS ANTI-CANCER AGENTS | AstraZeneca AB (SE) | 2007-03-14 | — | — | EP | claimed |
| WO-2005123696-A1 | SUBSTITUTED QUINAZOLONES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | claimed |