Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 17/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215754 | 0.88 | CNR2 (0.98) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5077165 | 0.87 | CNR2 (1.00) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5214874 | 0.86 | CNR2 (0.94) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5214258 | 0.86 | CNR2 (0.91) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5216776 | 0.82 | CNR2 (1.00) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5213345 | 0.80 | CNR2 (0.75) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5212031 | 0.80 | CNR2 (0.72) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5214656 | 0.80 | CNR2 (0.74) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5079688 | 0.80 | CNR2 (0.77) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5214293 | 0.79 | CNR2 (0.70) | CNR2CYP3A4CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565442-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2007-11-14 | — | — | EP | claimed |
| EP-1565442-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2007-11-14 | — | — | EP | disclosed |