Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.88 |
| ▸ | S1PR3 | Q99500 | 20/20 | 0.88 |
| ▸ | S1PR2 | O95136 | 18/20 | 0.88 |
| ▸ | LPAR2 | Q9HBW0 | 13/20 | 0.88 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.88 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846202 | 0.94 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195630 | 0.94 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195631 | 0.94 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195749 | 0.90 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195743 | 0.90 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195746 | 0.88 | S1PR1 (0.97) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195646 | 0.84 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195652 | 0.84 | S1PR1 (1.00) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL4875751 | 0.83 | S1PR1 (0.80) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL14195767 | 0.83 | S1PR1 (0.80) | S1PR1S1PR3S1PR2LPAR2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575964-A4 | N-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATES, PHOSPHONATES AND TETRAZOLES AS EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2007-04-04 | — | — | EP | disclosed |
| EP-1575964-A2 | N-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATES, PHOSPHONATES AND TETRAZOLES AS EDG RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| EP-1469863-A2 | SELECTIVE S1P1/EDG1 RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003061567-A2 | SELECTIVE S1P1/EDG1 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| WO-2003062248-A2 | N-(BENZYL)AMINOALKYLCARBOXYLATES, PHOSPHINATES, PHOSPHONATES AND TETRAZOLES AS EDG RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2003-07-31 | — | — | WO | disclosed |