Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.58 |
| ▸ | HRH2 | P25021 | 17/20 | 0.55 |
| ▸ | HRH1 | P35367 | 17/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213682 | 0.85 | HRH3 (0.65) | HRH3HRH2HRH1 | |
| SCHEMBL7220536 | 0.82 | HRH3 (0.59) | HRH3HRH2HRH1 | |
| SCHEMBL5214494 | 0.81 | HRH3 (0.60) | HRH3HRH2HRH1 | |
| SCHEMBL5215002 | 0.81 | HRH3 (0.65) | HRH3HRH2HRH1 | |
| SCHEMBL7220395 | 0.81 | HRH3 (0.57) | HRH3HRH2HRH1 | |
| SCHEMBL5216665 | 0.81 | HRH3 (0.59) | HRH3HRH2HRH1 | |
| SCHEMBL5214001 | 0.81 | HRH3 (0.62) | HRH3HRH2HRH1 | |
| SCHEMBL5221563 | 0.80 | HRH3 (0.64) | HRH3HRH2HRH1 | |
| SCHEMBL5219742 | 0.80 | HRH3 (0.64) | HRH3HRH2HRH1 | |
| SCHEMBL5220410 | 0.80 | HRH3 (0.58) | HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-B1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LAB (US) | 2007-09-12 | — | — | EP | claimed |
| US-6620839-B2 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | ABBOTT LABORATORIES | 2003-09-16 | — | — | US | disclosed |