Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.30 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.30 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215255 | 1.00 | GPBAR1 (0.36) | GPBAR1RAB9ATYK2GAAHTT | |
| SCHEMBL5212495 | 0.84 | NPC1 (0.38) | RAB9AGAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL5212496 | 0.84 | NPC1 (0.38) | RAB9AGAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL5354872 | 0.84 | DRD4 (0.36) | RAB9AGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5455414 | 0.84 | GSK3B (0.33) | RAB9AGAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL5455411 | 0.84 | GSK3B (0.33) | RAB9AGAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL5354877 | 0.84 | DRD4 (0.36) | RAB9AGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5351150 | 0.80 | SMN1; SMN2 (0.56) | GAAHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5351152 | 0.80 | SMN1; SMN2 (0.56) | GAAHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5943225 | 0.78 | C1S (0.35) | GAAMAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453830-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | GUDMUNDSSON KRISTJAN | 2007-07-12 | — | — | US | disclosed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION | 2004-12-09 | — | — | US | disclosed |
| EP-1453830-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SmithKline Beecham Corporation (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050120-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | HRH4, HRH2, HRH1 | GPBAR1 466/4885RAB9A 2498/4885TYK2 2162/4885 |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | HRH4, HRH1, HRH2 | GPBAR1 424/4885RAB9A 2596/4885TYK2 1917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.