Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.88 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.88 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464918 | 0.94 | MAPK14 (1.00) | MAPK14MAPK11HSPB1CYP2C9 | |
| SCHEMBL5116940 | 0.91 | MAPK14 (0.79) | MAPK14MAPK11HSPB1CYP2C9MAP2K1 | |
| SCHEMBL5632508 | 0.86 | MAPK14 (1.00) | MAPK14MAPK11HSPB1CYP2C9 | |
| SCHEMBL3072596 | 0.84 | MAPK14 (0.82) | MAPK14MAPK11HSPB1CYP2C9MAP2K1 | |
| SCHEMBL5456110 | 0.82 | MAPK14 (1.00) | MAPK14MAPK11HSPB1CYP2C9 | |
| SCHEMBL5462512 | 0.82 | MAPK14 (0.90) | MAPK14MAPK11HSPB1CYP2C9 | |
| SCHEMBL5465612 | 0.81 | MAPK14 (1.00) | MAPK14MAPK11HSPB1CYP2C9 | |
| SCHEMBL5629868 | 0.80 | MAPK14 (0.88) | MAPK14MAPK11HSPB1CYP2C9 | |
| SCHEMBL5463535 | 0.80 | MAPK14 (0.75) | MAPK14MAPK11MAP2K1 | |
| SCHEMBL6744546 | 0.80 | MAPK14 (1.00) | MAPK14MAPK11HSPB1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425555-B2 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-16 | — | — | US | disclosed |
| US-7425555-B2 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | disclosed |