Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 17/20 | 0.60 |
| ▸ | ABCC9 | O60706 | 15/20 | 0.60 |
| ▸ | ABCC8 | Q09428 | 11/20 | 0.60 |
| ▸ | KCNJ8 | Q15842 | 11/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216424 | 1.00 | KCNJ11 (0.60) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL5212875 | 0.92 | KCNJ11 (0.58) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL5212871 | 0.92 | KCNJ11 (0.58) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL5214753 | 0.91 | KCNJ11 (0.62) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL5214748 | 0.91 | KCNJ11 (0.62) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL4678184 | 0.90 | KCNJ11 (0.67) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL4678190 | 0.90 | KCNJ11 (0.67) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL4266846 | 0.90 | KCNJ11 (0.67) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL4266843 | 0.90 | KCNJ11 (0.67) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 | |
| SCHEMBL13949268 | 0.90 | KCNJ11 (0.67) | KCNJ11ABCC9ABCC8KCNJ8CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198456-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2007-09-19 | — | — | EP | claimed |