Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672893 | 1.00 | HDAC8 (0.38) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5217887 | 1.00 | HDAC8 (0.38) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5673828 | 0.94 | HDAC8 (0.40) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5673822 | 0.94 | HDAC8 (0.40) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5675449 | 0.92 | HDAC1 (0.41) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5675452 | 0.92 | HDAC1 (0.41) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5672139 | 0.88 | PPARG (0.46) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5672132 | 0.88 | PPARG (0.46) | HDAC8HDAC6HDAC1HDAC11APP | |
| SCHEMBL5213107 | 0.88 | HDAC8 (0.36) | HDAC8HDAC6HDAC1HDAC11PPARG | |
| SCHEMBL5214924 | 0.88 | HDAC8 (0.36) | HDAC8HDAC6HDAC1HDAC11PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060721-B1 | Imidazole compounds and medicinal use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2006-06-13 | — | — | US | claimed |
| EP-1142879-A1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | claimed |
| EP-1142879-B1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | ASTELLAS PHARMA INC (JP) | 2007-10-10 | — | — | EP | disclosed |
| US-7060721-B1 | Imidazole compounds and medicinal use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2006-06-13 | — | — | US | disclosed |
| EP-1142879-A1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |