Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256274 | 0.82 | GRM5 (0.40) | GRM5MKNK1PDE10AGRM4 | |
| SCHEMBL5218681 | 0.81 | PDE10A (0.39) | PDE10ADYRK1B | |
| SCHEMBL30794399 | 0.79 | GRM5 (0.62) | GRM5MKNK1PDE10AGRM4METAP2 | |
| SCHEMBL3917705 | 0.79 | GRM5 (0.62) | GRM5MKNK1PDE10AGRM4METAP2 | |
| SCHEMBL3923675 | 0.78 | GRM5 (0.45) | GRM5PDE10ADYRK1BIRAK4 | |
| SCHEMBL5216133 | 0.72 | GRM5 (0.42) | GRM5MKNK1GRM4 | |
| SCHEMBL5222668 | 0.71 | NPC1 (0.45) | GRM4DYRK1B | |
| SCHEMBL5217060 | 0.69 | NPC1 (0.41) | MKNK1PDE10AGRM4 | |
| SCHEMBL5219719 | 0.68 | MAPT (0.43) | PDE10AGRM4DYRK1B | |
| SCHEMBL5215415 | 0.68 | GRM2 (0.43) | GRM5MKNK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458383-B1 | HETEROARYL SUBSTITUTED PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2007-11-21 | — | — | EP | claimed |