Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815572 | 1.00 | TACR1 (0.57) | TACR1TACR3 | |
| SCHEMBL4815566 | 1.00 | TACR1 (0.57) | TACR1TACR3 | |
| SCHEMBL3091770 | 0.96 | TACR1 (0.56) | TACR1TACR3 | |
| SCHEMBL12809412 | 0.96 | TACR1 (0.56) | TACR1TACR3 | |
| SCHEMBL13756723 | 0.94 | TACR1 (0.54) | TACR1TACR3 | |
| SCHEMBL4814958 | 0.88 | TACR1 (0.56) | TACR1TACR3 | |
| SCHEMBL5217896 | 0.88 | TACR1 (0.56) | TACR1TACR3 | |
| SCHEMBL4814953 | 0.88 | TACR1 (0.56) | TACR1TACR3 | |
| SCHEMBL12809396 | 0.85 | TACR1 (0.61) | TACR1TACR3 | |
| SCHEMBL4822711 | 0.85 | TACR1 (0.58) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581517-B1 | SUBSTITUTED 1-PIPERIDIN-4-YL-4-AZETIDIN-3-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2007-02-21 | — | — | EP | claimed |
| US-7435736-B2 | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-10-14 | — | — | US | disclosed |
| US-7435736-B2 | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-10-14 | — | — | US | disclosed |