SCHEMBL5219133

SCHEMBL5219133

COc1ccccc1Oc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2OC(C)=O)CC3)c1

nearest known ligand 0.71

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 16/20 0.71
KCNH2 Q12809 11/20 0.71
CHRM2 P08172 1/20 0.56
CHRM3 P20309 1/20 0.56
CYP2D6 P10635 1/20 0.51
TSHR P16473 1/20 0.51
MGLL Q99685 1/20 0.50
LMNA P02545 1/20 0.49
HTT P42858 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4236177 0.89 CCR8 (0.73) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4234679 0.88 CCR8 (0.69) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4233294 0.86 CCR8 (0.69) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL5197543 0.85 CCR8 (0.71) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL2076736 0.85 CCR8 (0.74) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL5225972 0.85 CCR8 (0.75) CCR8KCNH2CYP2D6TSHRMGLL
SCHEMBL5255658 0.84 CCR8 (0.72) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL2074538 0.84 CCR8 (0.82) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4234799 0.83 CCR8 (1.00) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL5194031 0.83 CCR8 (0.72) CCR8KCNH2CHRM2CHRM3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869044-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES AstraZeneca AB (SE) 2007-12-26 EP disclosed
WO-2006107253-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES ASTRAZENECA AB (SE) 2006-10-12 WO disclosed