Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.51 |
| ▸ | HTR3B | O95264 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630866 | 0.86 | PDE10A (0.53) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL27649158 | 0.84 | PDE10A (0.69) | HRH3KDM4EALDH1A1HSD17B10HTR3E | |
| SCHEMBL28803641 | 0.82 | HRH3 (0.58) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL16648730 | 0.81 | HRH3 (0.57) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL2596336 | 0.80 | PDE10A (0.81) | PDE10A | |
| SCHEMBL1727542 | 0.79 | HRH3 (0.52) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL3289098 | 0.78 | DRD3 (0.43) | KDM4EALDH1A1CYP3A4HSD17B10PDE10A | |
| SCHEMBL2631079 | 0.78 | HRH3 (0.65) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL31381307 | 0.78 | PDE10A (0.68) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL16769735 | 0.78 | HRH3 (0.57) | HRH3KDM4EALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664025-B1 | PYRROL DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2007-09-19 | — | — | EP | disclosed |