Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 19/20 | 0.52 |
| ▸ | HTR1B | P28222 | 10/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093578 | 0.84 | HTR1D (0.56) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL6812048 | 0.84 | HTR1D (0.56) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL8554662 | 0.78 | HTR1D (0.46) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL5088740 | 0.76 | HTR1D (0.53) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL6808402 | 0.76 | HTR1D (0.53) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL6995726 | 0.76 | HTR1D (0.48) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL6811129 | 0.76 | HTR1D (0.52) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL5093705 | 0.76 | HTR1D (0.52) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL8550172 | 0.73 | HTR1D (0.46) | HTR1DHTR1BHTR1ADRD2HTR2A | |
| SCHEMBL8551188 | 0.72 | HTR1D (0.78) | HTR1DHTR1BHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458703-B1 | ISOCHROMAN COMPOUNDS FOR TREATMENT OF CNS DISORDERS | LILLY CO ELI (US) | 2007-02-28 | — | — | EP | disclosed |