Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 8/20 | 0.50 |
| ▸ | SRC | P12931 | 6/20 | 0.50 |
| ▸ | CDK2 | P24941 | 12/20 | 0.43 |
| ▸ | CDK4 | P11802 | 8/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310238 | 0.89 | CDK2 (0.56) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL4397546 | 0.82 | CDK2 (0.50) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL4385552 | 0.79 | SYK (0.50) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL4384008 | 0.76 | SYK (0.48) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL4388111 | 0.75 | SYK (0.54) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL5227039 | 0.75 | SYK (0.54) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL5620875 | 0.74 | CDK2 (0.76) | CDK2CDK4CDK1CDK7CDK9 | |
| SCHEMBL5621800 | 0.73 | CDK2 (0.70) | CDK2CDK4CDK1CDK7CDK9 | |
| SCHEMBL4393948 | 0.73 | CDC7 (0.59) | SYKZAP70SRCCDK2 | |
| SCHEMBL5620822 | 0.72 | CDK2 (0.69) | SYKSRCCDK2CDK4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751146-A2 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | Cyclacel Limited (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005075468-A2 | PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |