Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222191 | 0.94 | CNR2 (0.49) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5215497 | 0.89 | ESR1 (0.60) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5219512 | 0.83 | CNR2 (0.61) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5214017 | 0.82 | MAPK1 (0.51) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5218508 | 0.82 | CNR1 (0.46) | CNR2CNR1PPARA | |
| SCHEMBL5215832 | 0.81 | ESR1 (0.56) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5221678 | 0.81 | ESR1 (0.69) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5214152 | 0.80 | ESR1 (0.42) | KDM4EGMNNUSP2LMNAESR1 | |
| SCHEMBL5218760 | 0.78 | CNR1 (0.43) | CNR2CNR1PPARA | |
| SCHEMBL5220810 | 0.77 | MAPT (0.53) | KDM4EGMNNUSP2LMNAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102753-B1 | PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2007-02-28 | — | — | EP | disclosed |