Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215869 | 0.85 | AHR (0.48) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5219139 | 0.83 | MIF (0.48) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5215762 | 0.83 | AHR (0.49) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5217889 | 0.81 | MAPT (0.47) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5220905 | 0.81 | AHR (0.47) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5216628 | 0.81 | AHR (0.47) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5218683 | 0.80 | MIF (0.45) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5215415 | 0.79 | GRM2 (0.43) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5218689 | 0.79 | MKNK1 (0.44) | MIFGRM2AHRMAPTALDH1A1 | |
| SCHEMBL5220309 | 0.79 | DHODH (0.49) | MIFGRM2AHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458383-B1 | HETEROARYL SUBSTITUTED PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2007-11-21 | — | — | EP | claimed |