Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10978870 | 0.87 | TDP1 (0.45) | TDP1POLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7473306 | 0.84 | POLB (0.45) | TDP1POLBALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7472280 | 0.84 | TDP1 (0.46) | TDP1POLBALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7468663 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL7476840 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL17049181 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1RECQLSMN1; SMN2 | |
| SCHEMBL7472335 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1NPC1L3MBTL1 | |
| SCHEMBL18371959 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL17049183 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1RECQLSMN1; SMN2 | |
| SCHEMBL18371960 | 0.81 | POLB (0.46) | TDP1POLBALDH1A1RECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852427-A1 | Biologically active 4H-Benzo [1,4] oxazin-3-ones | Ortho-McNeil Pharmaceutical, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1280784-B1 | BIOLOGICALLY ACTIVE 4H-BENZO 1,4|OXAZIN-3-ONES | ORTHO MCNEIL PHARM INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-6908908-B2 | Biologically active 4H-benzo [1,4] oxazin-3-ones | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-06-21 | — | — | US | disclosed |
| US-20030083329-A1 | Biologically active 4H-benzo [1,4] oxazin-3-ones | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-05-01 | — | — | US | disclosed |
| US-6555536-B2 | Antiproliferative agents; antidiabetic agents | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-04-29 | — | — | US | disclosed |
| EP-1280784-A2 | BIOLOGICALLY ACTIVE 4H-BENZO 1,4]OXAZIN-3-ONES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-02-05 | — | — | EP | disclosed |
| EP-0869949-B1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO MCNEIL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-20020165228-A1 | Biologically active 4H-benzo [1,4]oxazin-3-ones | ORTH-MCNEIL PHARMACEUTICAL INC. | 2002-11-07 | — | — | US | disclosed |
| WO-2001087862-A2 | BIOLOGICALLY ACTIVE 4H-BENZO[1,4]OXAZIN-3-ONES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
| US-5854242-A | Benzoxazine antimicrobial agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0869949-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| US-5696117-A | BACTERICIDE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1997017333-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083329-A1 | Biologically active 4H-benzo [1,4] oxazin-3-ones | PPARD, PPARA, PPARG | TDP1 2947/4885POLB 1650/4885ALDH1A1 219/4885 |
| US-20020165228-A1 | Biologically active 4H-benzo [1,4]oxazin-3-ones | PPARD, PPARA, PPARG | TDP1 2947/4885POLB 1650/4885ALDH1A1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.